Chemists will reduce implant rejection with soluble polymers


The staff of the Laboratory of Chemical Technologies is modifying the surface of the materials from which implants are made to replace bone. The approaches developed at TSU are important for solving one of the main tasks of implantology - reducing the inflammation that can lead to the rejection of a foreign body. To minimize risks, the chemists use biodegradable polymers and ion treatment of implants as a coating.

- We work with two materials - zinc oxide (porous ceramic) and hydroxyapatite, the production technologies of which were developed by TSU scientists, - says Daria Lytkina, one of the authors and the project executor. - Both substances are used for the manufacture of implants, the difference is that the first material is replaced with bone tissue over time, the second remains forever in the patient’s body. The most common complication that occurs after implant placement is the inflammatory process, which is the primary immune response to a foreign substance. Immune cells - monocytes and macrophages - perceive the implantation as an invasion and try to neutralize it.

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