TSU scientists' data will help in examining patients with stroke


Scientists from the TSU Laboratory of Neurobiology, in the course of a series of experiments conducted using a model of ischemic stroke in rats, obtained new data on the processes that occur in the focal point of brain damage. This information can be the basis of a noninvasive diagnostic method that assesses the degree of inflammation, to predict the course of the disease and choose a treatment strategy for patients who have survived a “vascular catastrophe”. The research results are published in the highly ranked International Journal of Molecular Sciences.

To study the formation of new neurons in ischemic stroke, a special method of labeling young neurons was created. TSU scientists, with colleagues from the KU Leuven (Belgium), designed a courier for transporting genetic material into brain cells - special vectors based on lentiviruses and adeno-associated viruses. A similar method of delivering genetic material is now being used in the development of some vaccines and drugs.

Genetic engineers inserted a ferritin protein gene and a special genetic sequence into the neutralized virus that helps to increase the production of ferritin only in young neurons. Young neurons that have accumulated ferritin-containing iron atoms can be seen using a special magnetic resonance imaging (MRI) protocol.

Read more: http://en.tsu.ru/news/tsu-scientists-data-will-help-in-examining-patients-with-stroke/