Scientists have learned how the nervous system behaves in ischemia
TSU neuroscientists studied the processes that occur in a total disturbance of the blood supply to the brain in the hippocampus - a portion called the memory manager. The immune cells of the central nervous system try to save it by breaking nerve connections and suppressing the hyperexcitation of neurons, their so-called excitotoxicity. New fundamental data are important for effective approaches to the prevention of cerebral ischemia in people at risk, for example, with severe cardiac pathologies. The research results were published in the highly-ranked International Journal of Molecular Sciences.
- Despite the importance of damage to the hippocampus, the features of damage to this section during cardiac arrest in humans and the time of occurrence of these injuries are poorly understood, - says Tatyana Ananyina, a co-author of the article and a staff member of the TSU Laboratory of Neurobiology. - We tracked these changes in a model of total ischemia in rats that suffered cardiac arrest for seven minutes. The most serious disorders occur precisely in the hippocampus because excitation from a huge number of neurons from other areas of the brain comes into this zone.