Laboratory for Human Ontogenetics
36, Lenin Ave., Tomsk, 634050, Russia;
Phone: +7 3822 513-146
Areas of Research
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Systematic search for signals of natural selection in human genome, connected with adaptation to the climatic-geographical conditions during settlement of modern man in Siberia, and revelation of adaptive genetic variants using genome-wide genotyping technologies and exom screening by next generation massively parallel sequencing technologies (NGS).
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Revealing genetic markers of neuro-psychiatric diseases using high capacity genome technologies.
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Analysis of global level of DNA methylations and revelation of particular differential-methylated gene locuses in the samples of atherosclerotic affected and non-affected arteries under atherosclerosis.
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Analysis of number of mitochondrial DNA copies variability under atherosclerosis and in connection with global level of human genome methylations.
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Mapping of cognitive impairment genes in patients with idiopathic mental deficiency by sequenation of entire genomes (exoms).
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Identification of new autosomal recessive mutations in genes, associated with intellectual dysfunctions, manifested in patients with mircodeletion syndromes as a consequence of hemizygous condition formation and analysis of pathogenic importance of discovered mutations using PCR in the real time and new generation sequenation.
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Development of new genetic test systems for medicine on the basis on genome technologies.
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Training of highly qualifies specialists and students, development of new lecture courses and improvement of existing ones.
Partners
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The Research Institute for Medical Genetics SB RAMS (Tomsk, Russia);
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Institute of Cytology and Genetics SB RAS (Novosibirsk, Russia);
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Research Institute for complex issues of cardiovascular diseases (Kemerovo, Russia);
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Laboratory of modern anthropology, Fudan University (Shanghai, PRC);
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Bioinformatics division, Department of preventive medicine, University of Southern California (Los Angeles, USA);
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Chair of medical genetics, Department of gynecology, obstetrics and pediatrics, University of Bologna (Italy);
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Department of human and medical genetics, Vilnius University (Lithuania);
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Department of clinical genetics, Glasgow hospital (Scotland);
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Department of clinical genetics, Copenhagen University Hospital (Danemark).
Centre of Excellence
Centre for High Technologies in MedicineQS subject
- Medicine
- Biological Sciences
